This paper proposes an optimal operation method that comprehensively considers the regulation capacity of regional flexible resources under high-proportion renewable energy penetration. Firstly， for the resources with flexible regulation capacity in the region， an output characteristic model is constructed. Secondly， fully taking into account the limitations of the traditional AC power distribution mode， an optimal operation model is established in the AC-DC hybrid distribution network under high-proportion renewable energy penetration. The chaotic simulated annealing beetle antennae search algorithm is adopted to efficiently solve this multi-variable mixed-integer programming problem. Finally， the proposed model is verified by combining the actual regional resource endowment and the improved IEEE 33-node system. The case study results confirm the rationality and effectiveness of the proposed model.