: Collaborative control of voltage and loss indices in distribution network has always been an important work and has been highly valued． In the renewable energy environment，the coordinated control of voltage and loss index in distribution network is more difficult and challenging． According to the changing relationship and interaction characteristics of each physical quantity in distribution network，physical quantity are divided into three types: independent parameter variable，state variable and control variable，voltage and loss operation index of distribution network under new energy environment is established，and the sensitivity matrix for power flow distribution，node voltage and loss of distribution network is constructed for distributed generation and traditional reactive power compensation devices． Taking the local voltage stability index as the technical index， and the investment and operation and maintenance cost of the distributed generation as the economic index，the impact of large － scale distributed generation on the voltage and power loss is analyzed． The simulation results of an example of the IEEE 30 system verify the applicability and feasibility of the proposed method．