In order to fully excavate the potential in complementarity between multiple energy sources，the configuration of the hybrid energy system in industrial park is transformed from traditional extensive type to accurate optimization，and the conservatism of system configuration scheme is reduced． Based on PSO and CPLEX algorithm，the system configuration and operation scheduling of industrial parks are analyzed and optimized． A biological park is taken as an example for analysis，and the best design and operation strategies under the objective function are obtained． The simulation results show that the application of the proposed optimal configuration method can coordinate the utilization of various kinds of energy sources and enhance the comprehensive energy economic benefit of the system． At the same time，it provides a reference support for the planning and design of energy supply projects in industrial parks，and enriches design methods．