Abstract: Scientific division of power supply units is the key to the selection of the wiring mode of medium-voltage distribution networks. The traditional division of power supply units is usually based on the average load density and power supply radius,and it is difficult to deal with the massive amount of precise load spatial distribution information（such as longitude,latitude,and load size,etc.）. In this paper,a clustering division method for power supply units considering load distribution is proposed. First,based on the spatial coordinates and load size of the load in the power supply grid,a sample set of accurate load spatial distribution data is constructed. Second,the load intensity index is defined to quantify the tightness of the load distribution within the power supply unit,and the unit dispersion index is defined to quantify the clarity of the boundaries between the power supply units,and the objective function is constructed,and the clustering algorithm is used to traverse and optimize,and obtain the initial power supply unit division scheme. Further considering the technical guidelines,the constraint conditions are defined,including the maximum power supply radius,capacity-load ratio and total load. The initial division scheme which meets the technical guidance is adjusted to make the internal load distribution of the power supply unit as close as possible and the boundary between the power supply units as clear as possible. Finally,based on the three-dimensional information of the actual load space distribution of a power grid,Kmeans and DPC clustering algorithms are used to verify that the proposed method effectively considers the actual spatial distribution of the loads. The internal load distribution of the divided power supply unit is close,and the boundaries between the divided power supply units are clear.