Abstract: Energy loss is the main source of energy consumption in the power grid; technical loss reduction is an effective means of reducing power grid energy loss by adjusting the economic operation mode or technical transformation of equipment while ensuring the power grid's reliability. This paper starts with studying the factors affecting power grid loss. It reviews the research status of regional power grid technical loss reduction measures in six aspects and loss reduction potential evaluation methods. It is pointed out that in the specific implementation of technology loss reduction, it is necessary to accurately evaluate the loss reduction potential and optimize and integrate multiple loss reduction measures to obtain the optimal energy-saving benefits. At the same time, the overall architecture and main functions of the technology loss reduction visualization cloud platform are introduced, providing a digital and procedural idea for developing technical loss reduction. Finally, further research directions of regional power grid technical loss reduction are considered and prospected for readers' reference.