Abstract: Hydrogen production from renewable energy is one of the effective ways to reduce the high waste electricity of new energy and increase the proportion of green hydrogen. The multi-alkaline electrolyzers optimization operation strategy is proposed considering flexible electric loads and hydrogen loads in response to the optimization operation of large-scale new energy hydrogen production systems and high abandonment of electricity. Firstly, after considering the demand for electricity and hydrogen loads on the user side, transferable electric loads and hydrogen load models are established based on the transferable characteristics of electricity and hydrogen. Secondly, the multi-stack electrolyzer optimization operation strategy is proposed, considering the operating characteristics of a single electrolytic cell and electrolytic efficiency. Satisfying system operation constraints and optimizing the operating model to minimize economic cost is established and solved using the Yalmip toolbox and Cplex. The calculation results show that the participation of transferable loads can promote wind power consumption, reduce system electricity consumption, and improve the system economy. Compared with the multi-stack electrolyzer rotation strategy, the strategy proposed in this article effectively reduces the start and stop times of the electrolyzer, stabilizes the standard deviation of electrolysis cell power fluctuation within 0.27, improves the service life of electrolyzer arrays and increases the overall electrolysis efficiency to about 57%.