Abstract: The joint optimal regulation of the multiple controllable resources is of great significance in improving the security and economy of the distribution network operation. But it also increases the complexity of the optimization models and greatly reduces the computational efficiency. For this reason, a coordinated optimal regulation for the source-grid-load-storage of the distribution network based on the Fisher period division is proposed in this paper. Firstly, a coordinated optimization architecture for source-grid-load-storage with multi-time scales is constructed. It includes three stages, the day-ahead optimization, the intraday rolling optimization and the second-level supervisory control. Secondly, based on the source and load power interval data, a Fisher optimal period division is presented. Then, the day-ahead optimization model, the intraday rolling optimization model and the regional autonomous optimization model are formulated to obtain the optimal regulation schemes for the discrete equipment, the demand response loads, the photovoltaics and the energy storages. Finally, taking the IEEE 33-node system as an example, the proposed coordinated optimization control strategy is verified by simulation. The numerical results show that the proposed method is able to effectively improve the computational efficiency of the coordinated optimization model, ensuring the security and economy of the power grid operation.