Abstract: With the rapid development of smart grid technology, the integrated automation technology of substations has achieved significant improvement. However, the automatic operation functions of monitoring, operating and maintaining are not perfect. For example, the switching operation depends mostly on the traditional manual operation with one step after another, which is inefficient and far from meeting the development needs of the power system. Based on the dispatching and control cloud platform, the cloud-edge coordination cooperation technology is used to realize the integrated online management and control in the whole process of delivering the dispatching order, getting the operation ticket, rehearsing and operating, which improves the efficiency and accuracy of the substation switching operation. Firstly, the cloud and the edge sides are determined based on the business roles of the cloud center, the workstations of the anti-misoperation, and the mobile APPs during the substation switching operation. Then, based on the whole process of the switching operation, the mechanisms of cloud-edge interaction and cloud-edge cooperation are designed to form a switching anti-misoperation platform with the "full perception of the running status, full process of the anti-misoperation, full online of the operation and full cooperation of the business" operation. The reputation mechanism is introduced to improve the anti-misoperation accuracy of the edge nodes. Finally, through experiments, the performance evaluation, system scalability and anti-misoperation accuracy of the cloud-edge model are verified and analyzed. The results show that the anti-misoperation platform designed in this paper has a certain advantages in improving the switching operation efficiency and accuracy.