Abstract: Based on the characteristics of 5G communication, the problems of self-healing systems applied to 5G communication are analyzed. From the aspects of real-time data, system maintainability, and communication traffic, this paper analyzes three communication topologies of self-healing system devices: point-to-point connections, hand-in-hand connections, and forwarding through self-healing switch devices. A self-healing control system solution based on 5G communication is proposed. An analysis was conducted on the impact of data timeliness issues caused by 5G delay jitter on self-healing logic. A method with absolute time scale was proposed to distinguish effective data and achieve multi-source data synchronization. By integrating online monitoring and operation and maintenance functions, it provides a new idea and direction for the development and optimization of self-healing system. Finally, RTDS modeling and simulation verification were conducted on the proposed scheme in a 5G commercial environment, confirming that this scheme can achieve load transfer in the hundreds of milliseconds at any number of self-healing switches.