Abstract: To meet the requirement of close-range wireless communication and realize the intelligent interconnection of various information terminals, a SoC chip with Bluetooth 5.0 protocol is designed by using 40 nm eFlash CMOS technology. During the design process, the design method of the main functional modules of the system, such as power management, clock, storage and RF circuit, is studied based on the structure of the SoC chip. In order to improve the stability of the system, this paper presents a design method of high reliability circuit. Finally, the SiP system-level package scheme is adopted to expand the application scene of the Internet of things of the chip. The test results show that the chip can meet the application requirements of low power consumption and high reliability wireless communication system.