Abstract: With the increase of load and peak-valley difference in power systems, the electric consumption structure is continuously optimized. It is expected that hydropower can use its flexible start-stop feature on the power grid side to fully participate in the peakshaving of power grid for reducing the peak-valley difference of the system. The power plant side pursues the maximum cascaded electric quantity in the dispatching process to realize the maximum benefit. For the purpose of coordinating the contradictory demands on the cascaded power output process and simultaneously satisfying the complex constraints between the power plant and the power grid, the units of the cascaded hydropower station are taken as the dispatching unit, and the maximum cascaded power generation and the minimum peak-valley difference of the residual load in the power grid are selected as the objective function. The tie-line constraints on the power grid side and the constraints on the power plant side that are related to the water head such as tailwater jacking, output curve limit and irregular vibration areas, are fully considered and linearized. A multi-objective short-term mixed-integer linear programming（MILP） model is constructed under complex constraints to normalize the multi-objective function and transform it into a single objective function by weight method. The model is solved by Gurobi commercial solver.The practical application of the cascaded hydropower plants of Hongshui River in China, shows that the proposed model can get a cascaded generation plan which takes into account the goals and expectations on both sides of the power plant and the power grid.