Abstract: Pelagic islands are far away from the mainland. The current research focuses on utilizing renewable energy such as wind power and photovoltaic power to supply energy to the pelagic islands, which does not consider the shortage of pelagic land resource. In order to solve these problems, the wind/solar/wave energy resources of pelagic islands and their surrounding reefs are fully assessed. This paper designs an integrated construction and layout scheme of multi-energy reef power station, which utilizes new renewable power generating equipment including bladeless vortex wind turbine, the floating photovoltaic cell and the oscillating buoy wave energy capture device. Then, under equivalent annual investment cost and layout constraints, a mixed integer programming model for layout optimization and power generation potential exploration is proposed, whose objective function is to maximize total annual power generation. Finally, the model is solved by CPLEX, which is further compared with the calculation results by exhaustive method with different precision. The results verify that the proposed construction and layout scheme construction plan is reasonable and feasible, and has considerable power generation potential so that it can fully meet the electricity demand of pelagic island without excessive occupation of its land resources.