Abstract: With the advancement of electricity market reform, all provincial markets in East China region have been in the trial operation stage. In order to balance the smooth operation of the electricity spot market and the safe operation of regional power grid, it is urgent to study a more efficient region-province cooperative operation mechanism. First, the challenges and thoughts for the improvement of region-province scheduling cooperative mode under the background of electricity spot market are analyzed.Then, the feasible region models of the regional power grid scheduling and provincial and municipal scheduling are constructed,and the method for dimensionality reduction and linearization of the feasible region model is proposed. On this basis, a regionprovince cooperative and optimized operation mechanism based on the scheduling feasible region is proposed, which focuses on exploring the business process of region-province two-level cooperative operation and the calculation method of provincial and municipal feasible regions. Finally, the effectiveness of the scheduling feasible region model and the two-level market cooperative operation mechanism is verified through the analysis of regional power grid cases.