Abstract: In order to scientifically determine the number and location of energy stations and the distribution of energy supply pipelines in regional integrated energy system, the planning method of energy stations and pipelines considering topological characteristics of regional integrated energy system is proposed. Firstly, the topological characteristics of regional integrated energy system are summarized. According to the urban planning scheme and geographic information system, the optional energy station sites and pipeline channels are obtained. Secondly, a topological description model of energy system is established based on energy flow balance constraints and heating network characteristics. To minimize the cost of initial construction and later operation, the layout planning model of energy station and energy supply pipeline is established, and orthogonal polynomial approximation is used to simplify the optimization model. The simulation results show that the proposed method could obtain a more economical planning scheme.