Abstract: The long-term goal power grid is the basis for the adaptability analysis of the power grid planning scheme and the layout of the power facilities. The structure of the 220 k V power grid is relatively complex, and the security and reliability requirements of the power grid are high. At present, there is no typical grid model as a reference. Therefore, how to construct a safe and economical 220 k V long-term goal power grid is urgently needed for research. On this basis, a 220 k V long-term goal power grid planning method based on TSP optimization and power flow checking is proposed. This method first finds the shortest 220 k V power grid path through substation grouping and TSP optimization, ensuring the economy of the planning power grid structure, and then determines the tie-line type and number of the tie-line on the path through AC and DC power flow N-1 verification. Therefore, the planned power grid can pass through the N-1 safety check, thereby ensuring the safety and reliability of the planned power grid. The simulation results of a regional power grid show that the proposed method can construct a safe and economical 220 k V power grid and has practical engineering application value.