Abstract: In order to study the application effect and isolation performance of steel structure transfer stations in thermal power plants in high intensity areas, two typical steel structure transfer stations with two floors and five floors are established in this paper to study the isolation structure. The time history analysis of the structure is carried out by selecting 5 natural seismic waves and 2 artificial seismic waves, and the dynamic characteristics, inter story displacement angle, inter story shear force and other seismic response indexes of the structure before and after isolation are compared and analyzed. The conclusions are as follows: 1)The foundation isolation bearing in the transfer station structure in the high intensity area can effectively prolong the natural vibration period of the structure and reduce the seismic response strength of the structure. 2)After the structure is equipped with base isolation bearing, under the action of natural earthquake wave and artificial earthquake wave, the horizontal shear force at the bottom of the column, the displacement angle between floors, and the shear force between floors of the structure have been effectively reduced compared with those before isolation. It is suggested that the transfer station structure in high intensity areas should adopt structural isolation measures when conditions permit. 3)The difference of isolation effect of isolated structures is directly related to the yield weight ratio of the isolation layer, and reasonable control of the yield weight ratio of the isolation layer can effectively improve the isolation effect of structures. 4)During isolation design, the influence of structural deformation on process equipment shall be considered to eliminate additional stress caused by inconsistent deformation of adjacent buildings to ensure structural safety.