Abstract: In this paper, high arsenic（As） contaminated soil in a Hubei arsenic factory was taken as the research object. On the basis of previous studies, four commonly used leaching agents were combined and combined through oscillatory leaching experiment, the optimal combination of combined leaching was discussed, and the change of arsenic form before and after combined leaching and the release law of soil major elements during the leaching process were explored. The results showed that the leaching efficiency of 0.4mol/L KH2PO4+0.1 mol/L EDTA was the highest,reaching 66.99%, which was 31.23% higher than that of single leaching agent. All the three groups of compound leaching agents have a certain removal effect on the form of As, and the As in the soil after leaching mainly exists in the form of residue. The desorption of As eluted by KH2PO4+EDTA complex eluent is closely related to the release law of major elements such As Al, Fe and Ca. Residual As, which is difficult to remove in soil, may be wrapped in the crystal lattice of silicate minerals, thus limiting the desorption process of As in soil.