Abstract: Under the background of the new power system,this thesis is proposed in order to adapt to the demand for professional design of high-load, multi-main transformer and all-indoor substation architecture. By studying the principles and methods of the architectural design of non-traditional multi-main substations, this paper reviews and summarizes the architectural design of traditional indoor substations, discovering non-traditional, multi-substation,whole-house substation design concepts, design points and development trends, discussing from various perspectives such as the architectural layout, spatial form analysis, and construction room equipment configuration and size determination of the influencing factors of multi-main substations. It proposes design guidance from a few aspects, that are future multi-substation design methods, rational use of space, and resource saving, etc.