Abstract: Proton exchange membrane (PEM) hydrogen production by electrolysis technology is an efficient and environmentally friendly method for high-purity hydrogen production, and its pressure control in this process is important for the system efficiency, life and safety. The pressure control of hydrogen production by electrolysis system was studied to enhance the anti-disturbance performance of the system. Firstly, a dynamic pressure model was established and verified by experiments. Then, various control strategies, including proportional-integral-differential (PID), loop shaping, pre-filtering, and lead-lag compensation, were utilized to design hydrogen-oxygen pressure controllers. Finally, a simulation analysis of the controllers was conducted to determine the optimal parameter configuration with good stability and dynamic response. Results show that, the optimized control strategy enables the system to stably maintain hydrogen-oxygen pressure under fluctuating power, achieving efficient and stable operation of the system. The controller shows strong anti-disturbance ability and can accurately control the hydrogen-oxygen pressure.