Abstract: To solve the issue of difficult hydrogen storage and transportation, and to achieve efficient and clean utilization of methanol fuel, a combined heat and power system coupling fuel cell and organic Rankine cycle based on methanol reforming was proposed. In the proposed system, the reforming reaction of methanol with water under mid-low temperature condition yielded hydrogen-rich syngas. The chemical energy contained in hydrogen-rich syngas was converted to electricity in the fuel cell. The high temperature exhaust gas from the fuel cell could be used to heat the air and as a heat source for the organic Rankine cycle, and energy cascade utilization was achieved. Under the system steady operation condition, energy, exergy and economic analyses were carried out for the new system. Results show that the total output power of the new system is 147.372 kW, the system efficiency is 51.29%, and the system exergy efficiency is 40.56%. The dynamic payback period of the new system is 4.97 years. With a 15-year life span, the net present value is 1.279 4 million yuan.