Abstract: A control method of non-uniform flow jet was adopted, which meant that the flow rate of the tip jet hole was distributed in a quadratic curve along the axial chord length direction. Based on the LISA turbine, the influence of non-uniform flow jet on the tip clearance leakage flow under oblique blade tip shape was explored by numerical simulation.Results show that compared with the leading edge to trailing edge clearance from small to large, the non-uniform flow jet is more advantageous to control the gap flow in the tip gap with the leading edge to trailing edge clearance from large to small. Compared with no flow jet, the maximum increase of total isentropic efficiency of turbine can reach 2.20%, the maximum decrease of mass flow average total pressure loss coefficient on rotor outlet can reach 37.56%, and the maximum decrease of relative clearance leakage flow can reach 48.57%. When the jet flow ratio（the ratio of jet flow to main stream flow） is less than 1.0%, the distribution mode of large single-hole flow rate at the leading edge of the blade tip is adopted. When the jet flow ratio is larger than 1.0%, the single-hole flow rate in the middle of the blade tip is increased, and this non-uniform jet distribution pattern is more effective than the uniform flow distribution jet control.