Abstract: Due to the absence of any safety management and control solution suitable for the application of lithium-ion battery in power industry, there are obstacles to popularizing the application of DC power supply system with lithium-ion battery. In his paper, a safety management and control solution for DC power supply system with lithium-ion battery based on remote inspection is proposed. By means of multiple safety management & control units, multi-dimensional data monitoring and multi-level protective measures in the battery module of DC power supply system, the safety-protective measures corresponding to each hazardous level in the thermal runaway process of lithium-ion battery can be carried out before the hazards upgrade to next level. Through consistent guarding against the deviation of the safety-protective monitoring data from calibration status, the fluctuation of random error and the stabilization of systematic error in the remote inspection, the probability of inaccurate monitoring data can be continuously evaluated on line, and the preventive examine & repair for correcting the monitoring data can be conducted in need and intervene in time. The hazard test of the thermal runaway corroborated that the battery module can hold back the burning & explosion of combustible gas resulting from the thermal runaway and keep the thermal runaway from spreading outside, and the simulation test of accuracy evaluation for the monitoring data substantiated that the algorithm to output long-term early-warning and short-term alarm can determine the following monitoring data inaccuracy. The test results affirmed that this solution can effectively achieve the safety management and control of DC power supply system with lithium-ion battery.