Abstract: The deposition of corrosion products in the PWR primary circuit will not only reduce the heat transfer efficiency and increase the radioactivity level, but also lead to abnormal axial power deviation of core, which will seriously affect the safety of nuclear reactors. For better adapting to the change of power grid demand and improving economy,more and more reactors adopt more advanced and flexible fuel management strategies. In order to study the deposition behavior and radioactivity level of corrosion products in the primary circuit under different refueling strategies, this paper analyzes the 18-month refueling mode, 16/20-month alternate refueling mode and 24-month refueling mode respectively for a 1000 MWe PWR, and gives the optimal flexible fuel management strategy from the perspective of controlling deposition and radioactivity. The results show that the total CRUD amount and coolant radioactivity level are the least in 24-month refueling mode, compared to the highest in 16/20-month refueling mode. Considering corrosion controlling and radiation protection, the 24-month refueling mode has advantages.