Abstract: The traditional in-situ leaching method cannot economically, efficiently and environmentally exploit the ultra-low grade and low permeability uranium ore. In order to solve the problems of the low leaching efficiency of the low grade and low permeability uranium ore and the influence of the leaching process on the local ecological environment, the study progress of the in-situ leaching method on physical, chemical, microbiological and electrokinetic technology in recent 60 years are reviewed. Combined with the in-situ leaching method and the electrokinetic technique, it is found that the electrokinetic in-situ leaching（EK-ISL） technique mainly improves the uniform permeability of the solvent and the directional migration speed of ions through the action of electromigration and electroosmosis, so as to promote the dissolution of target minerals and gangues in the ore-bearing layer, significantly improve the permeability coefficient of the ore laye r and the leaching rate of uranium, and reduce the risk of solvent migration to the outside of the mining site under the targeted electric field. The application prospect of EK-ISL in low permeability and low grade uranium mining is very broad.