Abstract: At present, there are differences in the classification, analysis assumptions and acceptance criteria of all types of nuclear power reactor approved in China, and the configuration of the cooling system of the spent fuel pool is different, so is the safety level achieved and the influence on the overhaul flexibility of the unit. The purpose of this paper is to study the risk level of the spent fuel pool accident through the risk-guided method, and give reasonable suggestions on the management of spent fuel pool accident conditions and system configuration, so as to realize the balance of safety, overhaul flexibility and economy of nuclear power plants. The spent fuel pool accident management method for HPR1000 is to be continuously optimized.