Abstract: In this paper, the numerical simulation method is used to study the deposition law in the aerosol micro-channel under turbulent flow. The applicability of the Reynolds Stress Model（RSM） and the Discrete Phase Model（DPM） is verified by the experimental results of the Muyshondt experiment. The influence of the particle size and the gas flow rate on aerosol deposition is analyzed using the original DPM model, while the influence of the channel curvature on the aerosol deposition is studied using the modified DPM model with UDF considering the collision. The results show that in the case of turbulent flow, the dominant mechanism of the aerosol deposition in the microchannel is turbulent diffusion. Turbulent diffusion mainly affects aerosol particles with smaller diameters. As the Reynolds number increases, turbulent diffusion increases, the overall particle deposition rate increases. In the curved channel, the deposition rate of aerosol particles first increases and then decreases with the change of the particle size. Due to the enhanced inertial collision effect, the overall particle deposition rate increases significantly compared with the horizontal channel. But further increasing the channel curvature has no significant effect on the overall particle deposition rate.