Abstract: This article concludes a process to figure out weakness points in nuclear power plants’ operation and management applying PSA model analysis method and based on PSA insight. The method is practiced in the HPR1000 of China, and made out two important management and design optimizations-“optimization of emergent boron injection system management” and “opti mization of additional emergent diesel generator access design”. The quantitative result shows that the Level one core damage frequency for internal events at power decreases about 10 percent as a result. This method contributes to the application of PSA insight and improvement of NPP operation safety,so it has the potential of further application in other NPPs.