Abstract: Cabinet rooms in nuclear plants are generally centralized arranged in the supervised area. Due to the economic index of the unit, the general layout of the nuclear island, the storey height of structures and item distribution, the size of cabinet rooms have limitations during the nuclear plants general arrangement of nuclear power plant. According to layout features of cabinet rooms, two layout types, including the serial layout and the parallel layout, are proposed in this article. Arrangements of air ducts are made in both layout types and an arrangement method of non-overlapping ducts is obtained.