Abstract: The main control room may lose control or lose habitability due to factors such as fire, which in turn will lead to the scenarios that the operators have to abandon the main control room to the remote shutdown station for nuclear power plant command and control.The quantification of the main control room abandonment scenarios is the key technica l element of the fire probabilistic safety analysis with certain difficulty, but conservative or expert judgment methods for quantitative analysis were often used in the domestic nuclear power engineering projects, and no detailed in-depth study was conducted. On the basis of studying the guidelines of NUREG-1921 and its supplementary version, and combining the actual situation of domestic nuclear power plants, the three phases of the main control room abandonment scenarios and its quantitative method were introduced. Meanwhile, talk-through interviews and quantification of the main control room abandonment scenarios in a domestic nuclear power plant were carried out. The case study shows that there are no specific procedures of the lose control scenario for the nuclear power plant, which resulting in a high human error probability. Though with a low conditional probability, the consequence of this scenario is severe, and it is recommended that relevant procedures should be added to the nuclear power plant. The proposed study is a reference for the quantification of the main control room abandonment scenarios for domestic nuclear power engineering projects.