Abstract: A certain amount of radioactive waste will be produced during the operation of nuclear power plants. It is necessary to implement effective on-line dose monitoring during the treatment and temporary storage of radioactive waste to ensure the effectiveness of radioactive control in nuclear power plants. The setting of channel threshold is the core of the monitoring system. In this paper, the radioactive monitoring channel of the solid radioactive waste treatment system of the M310 PWR nuclear power plant was taken as the object of study, and the threshold setting of the monitoring channel was simulated by the radiation dose calculation software（Microshield） system. At the same time, the optimal design of the solid radioactive waste treatment system for PWR nuclear power plant was proposed. The design has been implemented at some nuclear power plants.