Abstract: With the development of electronic and information technology and the change of international environment, autonomous and controllable industrial control system is becoming more and more important for the efficient and safe development of national economy. It is imperative to accelerate the improvement of the quality of domestic DCS system and promote the application process of domestic DCS and thermal automation equipment. Heavy-duty gas turbine is widely used in electric power industry. At present, its core technology, especially the core control technology is monopolized by GE, Mitsubishi, Siemens and other large companies. Strengthening the localization of gas turbine core technology is the main research direction in this field. Localization of gas turbine control system is of great significance for autonomous control in this field. Based on HNICS-T316 system, the R&D team has successfully developed intelligent and safe DCS based on domestic substitution. This paper combed the system architecture of HNICS-T316 from the localization, intelligence and industrial control network security. Furthermore, the application of intelligent control technology of HNICS-T316 was introduced from the representative coordinated intelligent predictive control and variable structure predictive control algorithm module. Lastly, the application prospect of national production safety intelligent DCS in gas turbine control system is analyzed.