Abstract: In order to obtain accurate power flow calculation results and effectively study the impact of power operation uncertainty on the system, a power flow calculation method considering wind power fluctuation is proposed. Using interval and affine arithmetic, the interval power flow model of power system is constructed. According to the static security index, the optimal configuration position of power flow controller is determined, the interval power flow optimization model of power system is established, and the model is solved based on NSGA-II algorithm to obtain the power flow calculation results. The test results show that when the crossover and mutation probabilities are 0.8 and 0.5 respectively, the results of voltage amplitude, system network loss and static security index are within the standard range, and the accuracy of power system interval power flow calculation results is high, which can effectively ensure the system static security, meet the needs of system power flow regulation and reduce the project cost. Key words: wind power fluctuation; power system; interval power flow; affine arithmetic; static safety index; configuration location