Abstract: Reasonable short-circuit capacity is an important basis to ensure the safe and stable operation of power systems with renewable energy. The topology optimization is an economical and flexible method to improve the short-circuit capacity of power grids. In this paper, the topology adjustment is considered into the multi-period operation optimization of power systems, and a multi-period iterated generation dispatch and topology optimization method with short circuit current constraints is proposed to ensure a proper short-circuit capacity level of power systems. This method uses scenarios to model the future multi-period maximum wind power outputs, and proposes a two-stage iterative optimization method to solve the proposed multi-period iterated generation dispatch and topology optimization model. In the first stage, the topology optimization model aiming at minimizing the total switching costs is solved to obtain transmission switching scheme that can improve the power system short-circuit current level. In the second stage, the multi-period generation dispatch problem is solved to minimize the total costs of power generation, wind curtailment and load shedding, whose results are further evaluated by the short-circuit current constraint verification. Finally, the effectiveness of the proposed method is verified through the case studies of a modified IEEE 30 bus system.