Abstract: As the rapid development of electrified wire netting scale, with a large number of intelligent equipment and the power grid operation that might produce massive, multivariate, complex data, which showing the characteristics of massive, multivariate and complex. In this paper, we first applied the data analysis methods such as time series and clustering to make descriptive and predictive analysis of massive data in power system. In addition, we further discovered the data association and potential additional value based on cloud computing technology, realizing real time data information of power system with cloud computing technology and reaching platform integration of "collection-identification-processing-integration". Secondly, in order to truly realize the power grid operation under risk control, controllability and long-term in control, based on the integrated platform we explored the establishment of a set “Proactive prevention, active response for the event, and proper disposal afterwards" all-round power grid operation safety management and control mechanism. Finally, the feasibility of the proposed security management and control mechanism was verified by a typical case in Tianjin region.