Abstract: With the development of electric power production and social reform in China, the internal and external environment faced by electric power enterprises is becoming more and more complex, in which the operation and maintenance management and safe operation of electric power equipment are particularly important. This paper focuses on the main content of operation and maintenance management and safe operation of electric power equipment, discusses the current situation and problems of operation and maintenance management, and analyzes the strategy of operation and maintenance management and safe operation of electric power equipment from many aspects, such as improving the comprehensive quality of employees, establishing a composite maintenance team, optimizing the risk assessment system of electric power equipment, strengthening the condition based maintenance of electric power equipment, improving the ability to handle unexpected emergencies, and improving the internal management mechanism, Provide certain support for the healthy operation of power equipment.