Abstract: In response to the problem caused by the continuous increase of monitoring signals in power dispatch and control work, this article designs a signal monitoring and intelligent decision-making system based on Python language. By reading the corresponding data forms in the database, data analysis, classification, and statistics are carried out to form the corresponding signal overview and data dashboard, and voice alarm is also carried out. For special signals or unrecognized signals, intelligent decision-making functions based on text similarity technology are adopted to automatically match corresponding signal processing strategies, assist monitoring personnel in signal processing, reduce the risk of missed monitoring, and help reduce the number of unplanned power outages and improve the reliability of power grid operation.